Endocrine Abstracts

Lay summary uses are multitudinous with their overall purpose being to engage the average person’s interest and thereafter increase their understanding of a subject unfamiliar to them. In medicine, there is rightly an emphasis on ensuring that a patient fully understands what is happening to them in order that they may become an effective participatory member in their own care. However, literacy levels are surprisingly low, even in developed nations, and it therefore foll...

These days, many children with a RET gene change are diagnosed through genetic screening programmes when there is a parent with the gene change. I wasn’t one of those children and was not diagnosed with MEN2 until I was 31 years old. My son was diagnosed through screening at 2 years old. I will share our family’s story of how we adjusted to the ’new normal’, and how we live with this condition day-to-day more than 20 years down the line. I will also share s...

Critically ill patients are exposed to high levels of corticosteroids during their illness. While corticosteroid treatment has a modest effect on illness severity and survival dependent on the underlying diagnosis, observational and randomized data suggests that it also influences long-term neuropsychiatric outcomes. The mechanisms by which corticosteroid exposure during acute illness alters long-term brain function and neuropsychiatric risk are unknown. Because of the importa...

Multiple endocrine neoplasia (MEN) disorders are autosomal dominantly inherited syndromes characterised by multi-glandular adenomas/carcinomas. AMEND is a charity providing support and information resources to MEN patients. A recent anonymous online patient survey was conducted by AMEND into the psycho-social impact of the conditions. 219 patients participated (n101 MEN1, n60 MEN2a, n26 MEN2b, n32 other) with a mean age of 47.5 years. 57% felt that their condition had a negati...

Introduction: Co-morbidity of DM t 2 and insulinoma is extremely rare. There are only some case reports of diagnosing insulinoma but they concern patients already diagnosed with DM t. 2. We present patient diagnosed at the same time with DM t. 2 and insulinoma.Case report: A 69-year-old female patient was admitted to hospital because of high blood pressure. Since 2 years she reported attacks of weakness, tachycardia and sweating within the day, usually s...

Obesity and overweight are nowadays very important health problems. Metabolic syndrome increases the risk of diabetes mellitus and coronary heart disease. Patients suffering from metabolic syndrome, especially males, are at greater risk of acute cardiovascular episodes, like heart infarct or brain stroke, than patients without this, widely accepted atheromatosis’ risk farctor. The aim of the study was assessment of possible relations of PPARγ genetic polymorphism and...

One of the important proangiogenic factors involved in the growth of normal and neoplastic tissues is vascular endothelial growth factor VEGF.Therefore we hypothesized, that serum VEGF concentration would differ between patients with metastatic and non-metastatic thyroid cancer, with multinodular goiter and healthy subjects. We also hypothesized that endogenous TSH stimulation would effect serum VEGF level. The study protocol was approved by the Ethical ...

The aim of the study was to estimate the influence of a thyroid remnants’ volume, postsurgical concentration of thyroglobulin and radioiodine dose on the early treatment efficacy of well differentiated thyroid cancer.Material and methods: We retrospectively analyzed 91 patients (76 females, 15 men) with well differentiated thyroid cancer.Results: Histological classification revealed 68.1% (62/91) papillary thyroid cancers, 25....

The activity of the hypothalamo–pituitary–adrenal axis (HPA) is under control of endocrine, nervous and immune systems, in which opioids and recently discovered ghrelin play important role. Mannan polysaccharide is often used as an alternatives to antibiotics, however, its role in the stimulation of the immune system is still uncertain. As a part of study dealing with the interaction of different factors during the growth and development the experiment was carried ou...

Introduction: Besides medullary thyroid carcinoma and other endocrinopathies, people with MEN 2B have intestinal ganglioneuromatosis. A recent MEN2B cohort study reported high rates of gastrointestinal (GI) symptoms: we hypothesized these might have a major impact on patients’ daily lives.Methods: An online survey was conducted among patients from Association for Multiple Endocrine Neoplasia Disorders (AMEND). This incorporated relevant elements fro...